Abstract :Cancer is one of the major causes of death in the world. Prostate cancer is common cancer
in western countries. Two types of prostate cancers are defined including hormone-dependent
and castration-resistant prostate cancer [1]. Hormone-dependent prostate cancer is sensitive to
hormonal therapy and anti-cancer drugs. However, drug resistance and metastasis are often occurred
in castration-resistant prostate cancer. Many researchers are searching bioactive compounds
from plants for chemoprevention and chemotherapy in prostate cancer [2,3]. Ginger belongs to
the Zingiberaceae family. Ginger is popular used as a spice and flavoring agent. During the past
decades, a lot of bioactive compounds were extracted, and several in vitro and in vivo studies were
investigated in many diseases including cancer prevention, anti-inflammatory and anti-diabetic etc
[3]. The mechanism involved in the chemo preventive effects of ginger is contributed by free radical
scavenging, anti-oxidant and induction of apoptosis. Several phytochemicals such as gingerols,
shogaols, paradols, and gingerdiols have been characterized. 6 - Gingerol is abundant compound
in ginger and widely investigated in anticancer studies [4].